The Problem

Existing methods of drug discovery and testing are inadequate.
96% of drugs that pass pre-clinical trials never reach the market.

Current testing is limited to molecular biology only. Readouts from these tests—used to determine the safety and efficacy of treatment—don’t correspond to downstream physical functions including important activities like fluid flux, pressure development, and contractility. Models are not effective representations of humans. Widely-used Petri-dish, mouse and non-human primate disease models have been found to differ significantly from human disease and offer insufficient predictions for human treatment effects.

As a result, we've challenged ourselves to provide solution(s) for compromised preclinical drug testing, recover money lost on human clinical trials doomed to fail, and identify compounds typically lost during drug discovery.


The Solution

Revolutionary MechanoPharmacological tools with a suite of unique physical readouts.

We offer novel drug testing systems that provide both physical and chemical readouts, allowing for better determination of the safety and efficacy of drug candidates before they reach human trials. Our systems closely mimic human physiology, are compatible with standard microscopes, and are easy-to-use. Our products have already been implemented to make groundbreaking discoveries in the field of Polycystic Kidney Disease and are allowing other epithelial researchers to make significant strides in their respective fields.


Technology Platforms

Cyst Growth Platform

3D human/mouse cysts, HTS,
physiologically relevant, etc.

Screen Shot 2021-05-27 at 5.33.38 AM.jpg

Dixon, Eryn E., et al. Journal of cell science (2020).

Organ-Chip Platform

Human relevant physical readouts - barrier, toxicity,
pharmacokinetics, etc.

Screen Shot 2021-05-27 at 5.33.31 AM.jpg

US patent pending (WO2021007300A1), Choudhury, M. I., bioRxiv 727313